Citicoline Sodium
Citicoline sodium (CAS 33818-15-4) is the sodium salt of citicoline (CDP-choline), a white crystalline powder that dissolves readily in water and is used in cognitive-health formulations.
Identity
What it is.
Citicoline sodium is the monosodium salt of citicoline. It is the form described in the major pharmacopoeias and the one with the longest record of use worldwide.
In solution it has a near-neutral pH, which makes it the usual choice for liquid formulations. We manufacture it alongside free-form citicoline, so you can specify whichever suits your product.
Also known as: CDP-Choline sodium, Cytidine 5′-diphosphocholine sodium, Citicoline monosodium salt.
- CAS number
- 33818-15-4
- Molecular formula
- C₁₄H₂₅N₄NaO₁₁P₂
- Molecular weight
- 510.31 g/mol
- Appearance
- White crystalline powder
- Solubility
- Freely soluble in water
- HTS heading
- 2934.99
- Country of origin
- China
Specifications
Specifications.
Every batch is tested against the specification below and shipped with a certificate of analysis reporting the result and method for each test.
Citicoline Sodium 98%
White crystalline powder for liquids, capsules and tablets.
| Test | Specification | Method |
|---|---|---|
| Appearance | White crystals or crystalline powder, odourless | — |
| Solubility | Freely soluble in water; insoluble in ethanol and acetone | — |
| Identification | Colour reaction, HPLC, IR and sodium salt test | — |
| Assay (anhydrous basis) | NLT 98.0% | HPLC |
| pH | 6.0 – 7.5 | — |
| Loss on drying | NMT 6.0% | — |
| 5′-CMP | NMT 0.3% | HPLC |
| Any other single impurity | NMT 0.2% | HPLC |
| Total other impurities | NMT 0.7% | HPLC |
| Chlorides | NMT 0.05% | — |
| Phosphate | NMT 0.1% | — |
| Ammonium | NMT 0.05% | — |
| Iron | NMT 0.01% | — |
| Heavy metals | NMT 5 ppm | — |
| Arsenic | NMT 1 ppm | — |
| Residual solvents | Methanol NMT 0.3%; ethanol NMT 0.5%; acetone NMT 0.5% | — |
| Bacterial endotoxins | < 0.30 EU/mg | — |
Packaging and storage
- Packaging
- 25 kg cartons
- Shelf life
- 2 years from manufacture
- Storage
- Tightly closed, cool and dry
- Production
- Fermentation, at our plant in Xintai, Shandong
Regulatory
Regulatory status.
A summary for formulators and quality teams.
Standards
Monographs for citicoline sodium appear in several pharmacopoeias. We test to the monograph specified on your order, and the certificate of analysis states the method and limit for every test.
Use in the United States
We provide the regulatory documentation for our material with every quotation.
Documentation
Documentation, as standard.
Every shipment carries a certificate of analysis that names our manufacturing site, Xintai Jiahe Biotech Co., Ltd.. The full document pack is sent with your quotation, so your QA review can start straight away.
- Certificate of analysis for the batch
- Specification sheet
- Safety data sheet (SDS)
- Test methods
- FSSC 22000, ISO 9001, HACCP and Halal certificates
- Allergen statement
- GMO statement
- Residual solvent statement
- Heavy-metal results
- Country-of-origin statement
- Supply-chain traceability statement
Questions
Citicoline Sodium: common questions.
What is citicoline sodium?
Citicoline sodium is the monosodium salt of citicoline (CDP-choline). Its CAS number is 33818-15-4 and its formula is C₁₄H₂₅N₄NaO₁₁P₂. It is a white crystalline powder that dissolves freely in water.
How much citicoline does citicoline sodium contain?
By molecular weight, citicoline sodium is about 95.7% citicoline: 488.32 divided by 510.31. So 1.045 g of citicoline sodium supplies about 1 g of citicoline, before adjusting for assay and moisture.
Should I use citicoline or citicoline sodium?
For capsules, tablets and powders where you want the most citicoline per gram and no added sodium, use free-form citicoline. For liquids, or where your specification follows a pharmacopoeial monograph, citicoline sodium is the usual choice.
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