Citicoline (CDP-Choline)
Citicoline (CAS 987-78-0), also called CDP-choline or cytidine 5′-diphosphocholine, is a naturally occurring nucleotide supplied as a white crystalline powder for cognitive-health supplements and functional beverages.
Identity
What it is.
Citicoline is an intermediate in the body's own synthesis of phosphatidylcholine, a main component of cell membranes. As an ingredient it is one of the best-known compounds in the cognitive-health category, used in focus, memory and healthy-ageing formulas.
We manufacture citicoline in its free form, which contains no sodium and delivers more citicoline per gram than the sodium salt. It is the form most often chosen for capsules, tablets and powders.
Also known as: CDP-Choline, Cytidine 5′-diphosphocholine, Cytidine diphosphate choline, Citicoline free base.
- CAS number
- 987-78-0
- Molecular formula
- C₁₄H₂₆N₄O₁₁P₂
- Molecular weight
- 488.32 g/mol
- Appearance
- White crystalline powder
- Solubility
- Freely soluble in water
- HTS heading
- 2934.99
- Country of origin
- China
Specifications
Specifications.
Every batch is tested against the specification below and shipped with a certificate of analysis reporting the result and method for each test.
Citicoline 98%
White crystalline powder for capsules, tablets, powders and beverages.
| Test | Specification | Batch result | Method |
|---|---|---|---|
| Appearance | White crystalline powder | Conforms | — |
| Identification | IR, HPLC and chemical reaction | Conforms | — |
| Assay (dried basis) | NLT 98.0% | 99.1% | HPLC |
| Clarity and colour of solution | Clear and colourless | Conforms | — |
| pH | 2.5 – 3.5 | 2.8 | — |
| Loss on drying | NMT 5.0% | 3.4% | — |
| 5′-CMP | NMT 1.0% | 0.12% | HPLC |
| Free phosphoric acid | NMT 0.1% | < 0.1% | — |
| Ammonium | NMT 0.05% | < 0.05% | — |
| Heavy metals | NMT 10 ppm | < 10 ppm | — |
| Arsenic | NMT 2 ppm | < 2 ppm | — |
| Total plate count | NMT 1,000 CFU/g | < 10 CFU/g | — |
| Yeast and mould | NMT 100 CFU/g | 19 CFU/g | — |
| E. coli | Negative | Negative | — |
Packaging and storage
- Packaging
- 25 kg cartons
- Shelf life
- 2 years from manufacture
- Storage
- Tightly closed, cool and dry
- Production
- Fermentation, at our plant in Xintai, Shandong
Regulatory
Regulatory status.
A summary for formulators and quality teams.
Use in the United States
Citicoline is used in U.S. dietary supplements and functional beverages. We provide the regulatory documentation for our material with every quotation.
Standards
Each batch is tested by HPLC for assay and related substances, and the certificate of analysis states the method and specification for every test.
Documentation
Documentation, as standard.
Every shipment carries a certificate of analysis that names our manufacturing site, Xintai Jiahe Biotech Co., Ltd.. The full document pack is sent with your quotation, so your QA review can start straight away.
Request the document pack- Certificate of analysis for the batch
- Specification sheet
- Safety data sheet (SDS)
- Test methods
- FSSC 22000, ISO 9001, HACCP and Halal certificates
- Allergen statement
- GMO statement
- Residual solvent statement
- Heavy-metal results
- Country-of-origin statement
- Supply-chain traceability statement
Questions
Citicoline: common questions.
What is citicoline?
Citicoline, or CDP-choline, is a naturally occurring compound made of cytidine and choline joined by a diphosphate bridge. The body makes it as a step in building phosphatidylcholine for cell membranes. Its CAS number is 987-78-0.
What is the difference between citicoline and citicoline sodium?
Citicoline (CAS 987-78-0) is the free form. Citicoline sodium (CAS 33818-15-4) is its sodium salt. The free form contains more citicoline per gram and no sodium; the sodium salt has a near-neutral pH in solution and is the form described in most pharmacopoeias.
Is citicoline the same as CDP-choline?
Yes. Citicoline is the international non-proprietary name for cytidine 5′-diphosphocholine, which is abbreviated CDP-choline.
Is citicoline soluble in water?
Yes. Citicoline is freely soluble in water, which makes it suitable for shots, drink mixes and ready-to-drink beverages as well as capsules and tablets.
Quote Citicoline.
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